Cognitive fatigue

Cognitive fatigue (also called exhaustion, tiredness, lethargy, languidness, languor, lassitude, and listlessness) is medically recognized as a state usually associated with a weakening or depletion of one's mental resources. [1] [2] The intensity and duration of this effect typically depends on the substance consumed and its dosage. It can also be further exacerbated by various factors such as a lack of sleep [3] or food [4] . These feelings of exhaustion involve a wide variety of symptoms which generally include some or all of the following effects:

Cognitive fatigue is most commonly induced under the influence of moderate dosages of antipsychotic compounds, [5] [6] such as quetiapine, haloperidol, and risperidone. However, it can also occur during the withdrawal symptoms of many depressants [7] , and during the offset of many stimulants [8] .


  1. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.), 821. Arlington, VA: American Psychiatric Publishing. |
  2. Mizuno, K., Tanaka, M., Yamaguti, K., Kajimoto, O., Kuratsune, H., & Watanabe, Y. (2011). Mental fatigue caused by prolonged cognitive load associated with sympathetic hyperactivity. Behavioral and brain functions, 7(1), 17. |
  3. Alhola, P., & Polo-Kantola, P. (2007). Sleep deprivation: Impact on cognitive performance. Neuropsychiatric disease and treatment. |
  4. Kim, J. Y., & Kang, S. W. (2017). Relationships between dietary Intake and cognitive function in healthy korean children and adolescents. Journal of lifestyle medicine, 7(1), 10. |
  5. Seo, R. J., MacPherson, H., & Young, A. H. (2010). Atypical antipsychotics and other therapeutic options for treatment of resistant major depressive disorder. Pharmaceuticals, 3(12), 3522-3542. |
  6. Wittkampf, L. C., Arends, J., Timmerman, L., & Lancel, M. (2012). A review of modafinil and armodafinil as add-on therapy in antipsychotic-treated patients with schizophrenia. Therapeutic advances in psychopharmacology, 2(3), 115-125. |
  7. Risher-Flowers, D., Adinoff, B., Ravitz, B., Bone, G. H., Martin, P. R., Nutt, D., & Linnoila, M. (1988). Circadian rhythms of cortisol during alcohol withdrawal. Advances in alcohol & substance abuse, 7(3-4), 37-41. |
  8. Lago, J. A., & Kosten, T. R. (1994). Stimulant withdrawal. Addiction, 89(11), 1477-1481. |




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