Anxiety can be described as negative feelings of psychological apprehension, worry, and general unease. These feelings can range from subtle and ignorable to intense and overwhelming enough to trigger panic attacks and feelings of impending doom. Anxiety is often accompanied by nervous behavior such as rumination, fretting, restlessness, and muscular tension. As an emotion it is considered as distinct from fear in that feelings of anxiety are usually an exaggerated emotional response to an undesirable situation.

Psychoactive substance usage induced anxiety can be caused as an inescapable effect of the drug itself, by a lack of experience with the substance or intensity, as an enhancement of a pre-existing state of mind, or by the experience of negative hallucinations.

Anxiety is often accompanied by other coinciding effects such as depression and irritability. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as cannabinoids, psychedelics, dissociatives, and deliriants. However, it can also occur during the withdrawal symptoms of GABAergic depressants and during stimulant comedowns.

psychoactive substances

Compounds which may cause this effect commonly include:

1P-LSD, 2-Aminoindane, 2-FA, 2-FMA, 25B-NBOH, 25C-NBOH, 25C-NBOMe, 25D-NBOMe, 25I-NBOH, 25I-NBOMe, 25N-NBOMe, 3,4-CTMP, 3-FA, 3-FEA, 3-FMA, 3-FPM, 3-MMC, 3C-E, 4-FA, 4-FMA, 4F-EPH, 4F-MPH, 5-APB, 5-MAPB, 5-MeO-DMT, 5F-AKB48, 5F-PB-22, 6-APB, 6-APDB, A-PHP, A-PVP, AB-CHMINACA, AB-FUBINACA, ALD-52, APICA, Adrafinil, Alprazolam, Amphetamine, Armodafinil, Benzydamine, Bufotenin, Butylone, Caffeine, Cannabis, Cocaine, DOB, DOC, DOI, DPT, Datura, Dehydroxyfluorafinil, Desoxypipradol, Diazepam, Dichloropane, DPH, ETH-CAT, ETH-LAD, Efavirenz, Ethylone, Ethylphenidate, Harmala alkaloids, Hexedrone, Hexen, Ibogaine, Isopropylphenidate, JWH-018, JWH-073, LSA, LSD, Lisdexamfetamine, MCPP, MDA, MDAI, MDEA, MDMA, MDPV, Mephedrone, Methamphetamine, Methiopropamine, Methylnaphthidate, Methylone, Methylphenidate, Mexedrone, Modafinil, NEP, NM-2-AI, Nicotine, PMMA, Pentedrone, Piracetam, Prolintane, Propylhexedrine, STS-135, Salvinorin A, THJ-018, THJ-2201, Theacrine, Tyrosine, U-47700

See also

  • Anxiety suppression
  • Paranoia
  • Depression


Documentation written by Josie Kins and Jenny Kins