Cognitive fatigue

Cognitive fatigue can be described as a general feeling of mental exhaustion. The intensity and duration of this effect typically depends on the substance consumed and its dosage. It can also be further exacerbated by various factors such as a lack of sleep or food. These feelings of exhaustion involve a wide variety of symptoms which generally include some or all of the following effects:

  • Analysis suppression
  • Motivation suppression
  • Thought deceleration
  • Short term memory suppression
  • Thought disorganization
  • Language suppression
  • Creativity suppression

Cognitive fatigue is an extremely common effect under the influence of heavy dosages of antipsychotics, during the withdrawals of many depressants and during the offset of many stimulants.


psychoactive substances

Compounds which may cause this effect commonly include:

2-Aminoindane, 2-FA, 2-FMA, 2C-B-FLY, 3,4-CTMP, 3-FA, 3-FEA, 3-FMA, 3-FPM, 3-MMC, 4-FA, 4-FMA, 4F-EPH, 4F-MPH, 5-APB, 5-MAPB, 6-APB, 6-APDB, A-PHP, A-PVP, Alcohol, Amphetamine, Bromo-DragonFLY, Butylone, Caffeine, Cocaine, Datura, Desoxypipradol, Dextromethorphan, Dichloropane, Diphenhydramine, ETH-CAT, Ethylone, Ethylphenidate, Haloperidol, Hexedrone, Hexen, Isopropylphenidate, Lisdexamfetamine, MDA, MDAI, MDEA, MDMA, MDPV, Mephedrone, Methamphetamine, Methiopropamine, Methylnaphthidate, Methylone, Methylphenidate, Mexedrone, NEP, NM-2-AI, Pentedrone, Prolintane, Propylhexedrine, Selective serotonin reuptake inhibitor, Tianeptine, Tyrosine, U-47700

See also

  • Analysis suppression
  • Confusion
  • Thought deceleration

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Documentation written by Josie Kins