Depression can be described as a state of low mood and aversion to activity that can affect a person's general sense of well-being in a negative manner. Depressed people often feel sad, anxious, empty, hopeless, worried, helpless, worthless, guilty, irritable, hurt, or restless. They may have problems concentrating, remembering details, or making decisions and may contemplate or attempt to commit suicide.

Within the context of psychoactive substance usage, depression is often accompanied by other coinciding effects such as anxiety and irritability and can be considered as the polar opposite of cognitive euphoria. It is most commonly induced when a stimulant or depressant is used repeatedly for prolonged periods of time, during the withdrawal symptoms of almost any substance, or during the comedown/crash of a stimulant. However, it is worth noting that substance-induced depression is often much shorter lasting than clinical depression, subsiding once the effects or withdrawal symptoms of a drug have ended.

Outside of drug use and within the context of formal psychology, these feelings can be classified as clinical depression or major depressive disorder by the DSM's diagnostic criteria when five (or more) specific symptoms from the list below have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms must also be either (1) depressed mood or (2) loss of interest or pleasure.[1]

  1. Depressed mood most of the day, nearly every day, as indicated by either subjective report (e.g., feels sad, empty, hopeless) or observation made by others (e.g., appears tearful). (Note: In children and adolescents, can be irritable mood.)
  2. Markedly diminished interest or pleasure in all, or almost all, activities most of the day, nearly every day (as indicated by either subjective account or observation.)
  3. Significant weight loss when not dieting or weight gain (e.g., a change of more than 5% of body weight in a month), or decrease or increase in appetite nearly every day.
  4. Insomnia or hypersomnia nearly every day.
  5. Psychomotor agitation or retardation nearly every day (observable by others, not merely subjective feelings of restlessness or being slowed down).
  6. Fatigue or loss of energy nearly every day.
  7. Feelings of worthlessness or excessive or inappropriate guilt (which may be delusional) nearly every day (not merely self-reproach or guilt about being sick).
  8. Diminished ability to think or concentrate, or indecisiveness, nearly every day (either by subjective account or as observed by others).
  9. Recurrent thoughts of death (not just fear of dying), recurrent suicidal ideation without a specific plan, or a suicide attempt or a specific plan for committing suicide.

In order for a diagnosis of clinical depression to be fully accurate, the symptoms must cause clinically significant distress or impairment in social, occupational, or other important areas of functioning. The symptoms can not be attributable to the physiological effects of a substance or to another medical condition. The occurrence of the major depressive episode must also not be better explained by another disorder on the schizphrenic or psychotic spectrum.

If you suspect that you are experiencing symptoms of depression, it is highly recommended that you seek out therapy, medical attention, or a support group.

psychoactive substances

Compounds which may cause this effect commonly include:

2-Aminoindane, 2-FA, 2-FMA, 3,4-CTMP, 3-FA, 3-FEA, 3-FMA, 3-FPM, 3-MMC, 4-FA, 4-FMA, 4F-EPH, 4F-MPH, 5-APB, 5-MAPB, 6-APB, 6-APDB, A-PHP, A-PVP, Amphetamine, Benzydamine, Butylone, Caffeine, Cocaine, Datura, Desoxypipradrol, Dextromethorphan & Diphenhydramine, Dichloropane, Diphenhydramine, ETH-CAT, Ethylone, Ethylphenidate, F-Phenibut, Hexedrone, Hexen, Isopropylphenidate, Lisdexamfetamine, MCPP, MDA, MDAI, MDEA, MDMA, MDPV, Mephedrone, Methamphetamine, Methiopropamine, Methylnaphthidate, Methylone, Methylphenidate, Mexedrone, NEP, NM-2-AI, Pentedrone, Phenibut, Prolintane, Propylhexedrine, Selective serotonin reuptake inhibitor, Tyrosine, U-47700

See also


Documentation written by Josie Kins