Disinhibition can be described as a partial to complete suppression of one's self-restraint when it comes to governing socially acceptable behavior and general decision-making processes. A person with drug-induced disinhibition will experience a decreased ability to control and manage their immediate impulsive responses to the external environment. This is usually manifested through impulsivity, poor risk assessment, and a disregard for social conventions.
At its lower levels of intensity, disinhibition can allow one to overcome emotional apprehension and suppressed social skills in a manner that is moderated and controllable for the average person. This can often prove useful for those who suffer from social anxiety or a general lack of self-confidence.
However, at its higher levels of intensity, the disinhibited individual may be completely unable to maintain any semblance of self-restraint, sometimes at the expense of politeness, sensitivity, or social appropriateness. This lack of constraint can be negative, neutral, or positive depending on the individual and their current environment.
Disinhibition will often synergize with other coinciding effects, such as amnesia and anxiety suppression, in a manner which can further decrease one's observance of and regard for social norms. It is most commonly induced under the influence of common to heavy dosages of GABAergic depressants such as alcohol, benzodiazepines, phenibut, and GHB. It is also a commonly reported effect of entactogenic substances such as MDMA, methylone, and mephedrone.
Compounds which may cause this effect commonly include:
1,4-Butanediol, 2-FA, 2-FMA, 2-Fluorodeschloroketamine, 2C-B-FLY, 2M2B, 3,4-CTMP, 3-FEA, 3-FPM, 3-HO-PCE, 3-HO-PCP, 3-MMC, 3-MeO-PCE, 3-MeO-PCMo, 3-MeO-PCP, 4-AcO-DiPT, 4-FA, 4-FMA, 4-MeO-PCP, 6-APB, A-PHP, A-PVP, Alcohol, Alprazolam, Carisoprodol, Clonazepam, Cocaine, Deschloroetizolam, Deschloroketamine, Dextromethorphan, Diazepam, Dichloropane, Diclazepam, Diphenhydramine, Diphenidine, Efavirenz, Ephenidine, Etizolam, F-Phenibut, Flubromazepam, Flubromazolam, GBL, GHB, Hexedrone, Hexen, Ketamine, Lorazepam, MDA, MDEA, MDMA, Mephedrone, Methaqualone, Methoxetamine, Methoxphenidine, Methylone, Metizolam, NEP, Nifoxipam, O-PCE, PCE, PCP, Pentedrone, Pentobarbital, Phenibut, Phenobarbital, Poppers, Pregabalin, Propylhexedrine, Pyrazolam, Secobarbital, Temazepam, Tramadol, Zolpidem, Zopiclone, ΑMT
Documentation written by Josie Kins