Irritability enhancement

Irritability enhancement can be described as a cognitive effect which results in heightened feelings of stress, irritability, annoyance, and anger. These feelings are often further intensified by other accompanying effects such as anxiety, paranoia, and ego inflation.

This effect can sometimes result in a certain subset of people presenting a greater tendency towards exhibiting violent behaviors. However, the chances of somebody responding in such a way depends on the individual and differs wildly between people. It is also worth noting that an increased propensity towards violence typically only affects those who were already susceptible to aggressive behaviors.

Irritability enhancement most commonly occurs during the offset of heavy dosages of stimulants such as cocaine and methamphetamine. It has also been known to occur under the influence of alcohol.[1]


psychoactive substances

Compounds which may cause this effect commonly include:

2-Aminoindane, 2-FA, 2-FMA, 3,4-CTMP, 3-FA, 3-FEA, 3-FMA, 3-FPM, 3-MMC, 4-FA, 4-FMA, 4F-EPH, 4F-MPH, 5-APB, 5-MAPB, 6-APB, 6-APDB, A-PHP, A-PVP, Alcohol, Alprazolam, Amphetamine, Butylone, Caffeine, Clonazepam, Clonazolam, Cocaine, Creatine, Desoxypipradol, Diazepam, Dichloropane, Diclazepam, Diphenhydramine, ETH-CAT, Ethylone, Ethylphenidate, Etizolam, Flubromazepam, Flubromazolam, Hexedrone, Hexen, Isopropylphenidate, Lisdexamfetamine, MDA, MDAI, MDEA, MDMA, MDPV, Mephedrone, Methamphetamine, Methiopropamine, Methylnaphthidate, Methylone, Methylphenidate, Mexedrone, Mirtazapine, NEP, NM-2-AI, Nifoxipam, Noopept, Pentedrone, Piracetam, Prolintane, Propylhexedrine, Stimulant, Tyrosine, U-47700, Zopiclone


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Documentation written by Josie Kins