Spirituality enhancement can be described as the experience of a shift in one's personal beliefs and interests. It results in one holding notions of certain key concepts with higher regard than that which they did previously. These concepts and notions are not limited to but generally include:
- An increased sense of personal purpose.
- An increased interest in the pursuit of developing personal religious and spiritual ideologies.
- The formation of complex personal religious beliefs.
- An increased sense of compassion towards nature and other people.
- An increased sense of unity and interconnectedness between oneself, nature, god and the universe as a whole.
- A decreased sense of value placed upon finances and material objects.
- A decreased fear of death and the finite nature of existence.
- Although difficult to fully specify, these changes in one's personality and belief system can often result in profound changes in one's personality which can become distinctively noticeable to others around those who undergo it. This shift can occur suddenly but will usually increase gradually over time as a person repeatedly uses the psychoactive substance which is inducing it.
Sprituality enhancement is most commonly induced under the influence of moderate dosages of psychedelics such as psilocin, ayahuasca, DMT, LSD, and mescaline. However, it can also occur less commonly under the influence of heavy doses of dissociatives and entactogens. It is worth noting that this effect is unlikely to be an independent component within itself, but is more likely to be a result of a combination of other cognitive mindstates in conjunction with a proper setting which convey a wide variety of different themes. These effects generally include: Analysis enhancement, autonomous voice communication, novelty enhancement, perception of interdependent opposites, perception of predeterminism, perception of self-design, personal bias suppression, and unity and interconnectedness.
There have been a number of in-depth scientific studies which unanimously support the legitimate existence of the spiritual effects induced by hallucinogen usage.   
Frequently, new psychedelic users rate their experience to be either the single most meaningful experience of their life or among the top five most meaningful experiences of their life.
Any psychedelic or hallucinogen intentionally used for religious or spiritual purposes is known in the literature as an entheogen. The ritualized usage of entheogens for religious or spiritual purposes dates back thousands of years and is well established throughout both anthropological and modern evidence.
Compounds which may cause this effect commonly include:
1P-LSD, 2C-B, 2C-E, 2C-P, 4-AcO-DMT, 4-HO-MET, 4-HO-MiPT, ALD-52, Ayahuasca, Bromo-DragonFLY, DMT, DPT, LSA, LSD, LSM-775, LSZ, MET, Mescaline, PARGY-LAD, Psilocin, Psilocybin mushroom
Documentation written by Josie Kins